diff --git a/Misc/NEWS.d/next/Build/2018-02-07-11-24-38.bpo-32616.o7mFJ3.rst b/Misc/NEWS.d/next/Build/2018-02-07-11-24-38.bpo-32616.o7mFJ3.rst
new file mode 100644
index 00000000000000..cdddc2f2d909dc
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2018-02-07-11-24-38.bpo-32616.o7mFJ3.rst
@@ -0,0 +1,2 @@
+Disable computed gotos by default for clang < 5.0. It caused significant
+performance regression.
diff --git a/Python/ceval.c b/Python/ceval.c
index 4e4adc2d63dc1b..bae158dc1402b1 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -689,11 +689,19 @@ PyObject *
 PyEval_EvalFrameEx(PyFrameObject *f, int throwflag)
 {
 #ifdef DYNAMIC_EXECUTION_PROFILE
-  #undef USE_COMPUTED_GOTOS
+    #undef USE_COMPUTED_GOTOS
 #endif
 #ifdef HAVE_COMPUTED_GOTOS
     #ifndef USE_COMPUTED_GOTOS
-    #define USE_COMPUTED_GOTOS 1
+        #if defined(__clang__) && (__clang_major__ < 5)
+            /* Computed gotos caused significant performance regression
+             * with clang < 5.0.
+             * https://bugs.python.org/issue32616
+             */
+            #define USE_COMPUTED_GOTOS 0
+        #else
+            #define USE_COMPUTED_GOTOS 1
+        #endif
     #endif
 #else
     #if defined(USE_COMPUTED_GOTOS) && USE_COMPUTED_GOTOS